Covid Recovery Immune Support Pack2022-01-19T09:29:34+00:00

Covid recovery immune support pack

As experts in health and wellbeing we have developed a specialist pack of nutraceuticals to enhance your post-viral recovery.

  • Formulated by in-house Doctors
  • Science-based clinical evidence
  • High strength immune modulation in daily easy-to-use packs

As Seen In…

“The aim of this specialist nutraceutical pack is to reduce inflammation and to help the body recover as quickly as possible whilst avoiding the risks of long COVID. Doctors in clinics in the UK, including our own clinic, use these nutraceuticals to support the immune system.

Clinical trials are ongoing for a number of these minerals and vitamins for the treatment of COVID and long COVID and, as we await the publication of new data, we have selected those that appear to be of most benefit.

These are not a substitute for, nor should they be construed as, medical treatment.”

Dr Geoff Mullan, CEO humanpeople. 

Block viral replication

Impede replication

Reduce inflamation

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Long Covid (viral symptoms lasting beyond one month) affects 1.2 million people in the UK (Office of National Statistics)

When your body fights off Covid it can overreact. This leads to it damaging the delicate structure of your lungs and other organs. 

Nutraceuticals can target this overstimulation to reduce immune stimulation (viral load) or calm the overreaction to infection. 

Quercetin and resveratrol are potent antioxidants that reduce inflammation and viral replication. NAC boosts glutathione and antioxidant reserves whilst vitamin A and alpha lipoic acid are strong immune modulators.

These supplements are currently being used to treat long COVID symptoms.

Nutraceuticals in our packs to support the immune system

Each pack has six high strength nutraceuticals – read more about them below. For those people with mild to moderate infections our Doctors recommend using these packs for at least 4 weeks, or at least 2 weeks after the end of any symptoms such as tiredness or muscle stiffness.

If you are not currently taking omega 3 or vitamin D we strongly recommend supplementing with both of these.

See the end of article for a list of peer reviewed clinical evidence.

Reduce viral replication, balance the immune system, reduce inflammation.

How do nutraceuticals affect the immune response?

In many people COVID 19 creates a significant cytokine over-reaction or “storm”. It is this storm or “inflammasome” that is responsible for much of the damage. The most important being the “NLRP3 inflammasome-mediated IL-beta” production. Altering this response will alter the cytokine storm.

An enzyme called the main protease COVID 19 protein or “M PRO” is required for viral replication. A number of therapeutics and nutraceuticals may affect this mechanism.

So in summary, you need to reduce this inflammation over-reaction. To do this, healthy food, a healthy lifestyle and good sleep are all equally essential. Reducing the viral load by blocking viral replication will decrease the severity and duration, and at the same time boost both the adaptive and innate immune systems.

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Click on the button below for our article summarising the latest research into the effectiveness of nutraceuticals to help Covid recovery.
humanpeople article

FAQs

What is in the COVID recovery packs?2022-01-10T15:24:12+00:00

The severity and effects of COVID-19 infection have a wide range of symptoms many of which Doctors and researchers are still trying to fully understand. As this knowledge improves we are able to target specific mechanisms. Computer modelling, current knowledge of viral mechanisms and some early clinical trials have helped Doctors to appreciate which nutraceuticals and botanicals may help to support the immune system. We have been part of this conversation alongside a number of other Doctors.

If you are not currently taking vitamin D3 and omega 3 we strongly recommend you do so. You can do this by choosing our Essential Plus virus recovery pack, which contains everything in the Essential pack as well as omega 3 and vitamin D3.

  • Quercetin targets viral binding, replication and inflammation. Computational analysis has shown it can strongly bind the ACE2 receptor and disrupt Covid S spike protein entry into the cell. Furthermore, evidence shows quercetin blocks a protein releasing a protease called  Mpro, which acts as a lock cutter that breaks open a molecular box containing Covid replication machinery that takes over the human cell. Finally, quercetin inhibits inflammatory molecules that drive immune cells into an inflammatory frenzy that damages delicate lung tissue such as interleukin 1, 6, 8, TNF-alpha and IFN gamma overproduction.
  • Vitamin A is important for the growth and repair of lung tissues whilst also playing an important role in the immunity of mucus membranes. In the lungs and gut, Vitamin A is associated with sIgA levels. Covid reduces the absorption of vitamin A and needs to be boosted. Vitamin A smooths the levels of inflammatory molecules such as IL-6 and TNF-alpha by inhibiting the NF-kB inflammatory pathway. Studies show people who take vitamin A have reduced inflammatory markers such as CRP. Whilst also having a positive effect on innate immune cells and dendritic cells (the link between adaptive and innate branches of the immune system).
  • N-acetyl cysteine (“NAC”) glutathione is a strong antioxidant currently being assessed in over a dozen clinical trials for efficacy in COVID. NAC is converted into Glutathione. A defensive mechanism is used when cells are under stress or under attack. Mechanisms include preventing damage from reactive oxygen species and ‘deactivating’ harmful compounds (through powerful detoxification pathways). Essential when dealing with Covid induced inflammation.
  • Resveratrol is a powerful polyphenol antioxidant. Computer simulations along with biochemical assays show resveratrol could inhibit ACE2 and spike protein interactions which would decrease the virus ability to enter the cell. Evidence collected in vivo has shown it modulates cytokine and chemokine profile through the NF-kB pathway and inflammasomes.
  • Zinc is essential for maintaining immune strength. Zinc deficiencies are correlated to disease susceptibility. Zinc-dependent enzymes are needed to assist T helper cell function and proliferation. As well as Macrophage function.
  • Alpha lipoic acid increases T cell activation in elderly populations. Reduces damage from ROS in mitochondria which may be responsible for some of the long COVID symptoms such as headaches. And a meta-analysis shows ALA supplementation reduces CRP levels as well as other inflammatory markers. The mechanism for which is thought to be modulating the NF-kB inflammatory pathway.

 

Immune support packs contain:

Quercetin 400mg, NAC 600mg, Vitamin A 11,000 IU (300% NRV), Resveratrol 150mg, Elemental Zinc 50mg from 187mg zinc citrate (500% NRV), Alpha lipoic acid 300mg, Selenium 55 mcg (100% NRV), Vitamin C 90mg (110% NRV), Vitamin E from alpha tocopherol 30mg (250% NRV)

What can be done to help people with long COVID?2022-01-06T18:43:13+00:00

The disorder tends to be poorly understood. That said, Functional Medicine doctors are having success in using a holistic approach that includes improving lifestyle, improving gut health and diet and supporting with medicines and nutraceuticals. Private clinics in the UK offer in depth screening for COVID. No good data has yet been published on either approach.

Drugs that prevent clotting, including apixaban, are being trialed at Cambridge University.

 

Do other infections cause post-infection syndromes or is this new?2022-01-06T18:45:09+00:00

It is not uncommon for infections, especially those that affect the brain, to have long lasting symptoms and these were first reported in scientific journals over 100 years ago. It is possible that due to better recording and the scale of the pandemic that instead of being dismissed, like ME was for a long time, these symptoms will be taken seriously.

Chronic fatigue syndrome (“CFS”), or myalgic encephalitis (“ME”), that occurs after a viral infection in the brain is still contested because it had no clear biological underpinning. ME/CFS is often post-viral.

Will COVID-19 Lead to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome? Frontiers Jan 2021

 

What is the underlying science of long COVID?2022-01-06T18:46:44+00:00

The exact science is still being worked out, however a number of published papers have:

  • Shown that a lot of people with long COVID have it in multiple organs, suggesting it may be a multi organ problem. (1)
  • Provided evidence that the virus, or at least fragments of the virus, persists for months afterwards, particularly in the gut. Those with compromised gut health may not be clearing these reservoirs of virus or may be having an abnormal immune response to them due to poor gut health. (2)
  • Suggested there is an immune dysregulation causing things to go haywire and attack the body as is seen in autoimmune disease. (3)
  • PHOSP-COVID is a study of over 1000 patients in the UK where blood samples have been taken to look at inflammatory outcomes and changes to the clotting system. There is evidence that the virus persists and that there are changes in the inflammatory markers (cytokines) as well as markers that suggest brain dysfunction. (3),(4)

So, in summary, fragments or full virus can persist for a long time. Inflammatory markers remain changed over time.

  1. Ayoubkhani, D. et al. Preprint at medRxiv https://doi.org/10.1101/2021.01.15.21249885 (2021).
  2. Gaebler, C. et al. Nature 591, 639–644 (2021).
  3. Rogue antibodies could be driving severe COVID-19 Nature
  4. PHOSP-COVID Collaborative Group et al. Preprint at medRxiv https://doi.org/10.1101/2021.03.22.21254057 (2021).
Do more women than men get long COVID?2022-01-06T18:47:41+00:00

Doctors are reporting an increased infection rate among women compared to men. The UK government statistics suggest 23% of women and 19% of men have symptoms at 5 weeks.

  • If you’re male and get COVID you are more likely to go to hospital and die.
  • If you are female you are more likely to get ongoing symptoms.
  • It is most common in middle age (those between 35 and 49).
  • Long COVID in kids is being played down, however there is evidence that a percentage also suffer from long COVID symptoms.

Overall, middle aged females have the highest prevalence of long COVID.

What is long COVID?2022-01-06T18:38:32+00:00

Long COVID is generally agreed to be symptoms that last beyond 4 weeks. Long COVID in medical terms has now moved from the periphery to being accepted as a condition. In the UK long COVID clinics are now emerging to treat this condition specifically.

A recent study by neuroscientist Athena Akrami at University College London found 205 symptoms in a study of 3,500 people, but the most common are:

  • Fatigue
  • Post-exertional malaise
  • Cognitive dysfunction or brain fog

A study by the UK biobank is collecting brain, heart and body MRI scans. To be part of the study you can find out more here.

The UK Office of National Statistics reviewed over 20,000 people and reported that 13.7% of people still reported symptoms after 12 weeks of infection.

 

How will humanpeople help me?2022-01-06T18:48:45+00:00

Our approach is to find little issues and correct them before they become big problems.

Low energy, brain fog, skin inflammation or poor sleep can all be helped.

We make it easy and accurate. Our Doctor-led team use science to work out how to boost your health.

Our approach is to listen, understand your concerns then:

  1. Correct any blood deficiencies
  2. Compensate for any genetic weaknesses
  3. Rebalance and support gut health

Clincial evidence

Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability. Molecules, 26(10), p.2834. Gligorijević, N., Stanić-Vučinić, D., Radomirović, M., Stojadinović, M., Khulal, U., Nedić, O. and Ćirković Veličković, T. (2021).

Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients. Antioxidants, 10(9), p.1440. ‌‌Liao, M.-T., Wu, C.-C., Wu, S.-F.V., Lee, M.-C., Hu, W.-C., Tsai, K.-W., Yang, C.-H., Lu, C.-L., Chiu, S.-K. and Lu, K.-C. (2021).

Preventive Role of Resveratrol Against Inflammatory Cytokines and Related Diseases. (2019). Current Pharmaceutical Design, Rafe, T., Shawon, P.A., Salem, L., Chowdhury, N.I., Kabir, F., Bin Zahur, S.M., Akhter, R., Noor, H.B., Mohib, M.M. and Sagor, M.A.T.

Resveratrol inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in cultured Vero cells (2020). Phytotherapy Research,Yang, M., Wei, J., Huang, T., Lei, L., Shen, C., Lai, J., Yang, M., Liu, L., Yang, Y., Liu, G. and Liu, Y.

clinicaltrials.gov.

Therapeutic potential of N-acetyl cysteine (NAC) in preventing cytokine storm in COVID-19: review of current evidence (2021). . European Review for Medical and Pharmacological Sciences, 25(6), pp.2802–2807. Mohanty, R.R., Padhy, B.M., Das, S. and Meher, B.R.

The potential mechanism of N-acetylcysteine in treating COVID-19 (2020) Current Pharmaceutical Biotechnology, 22(12). Zhou, N., Yang, X., Huang, A. and Chen, Z.

Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CLpro and PLpro), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin-converting enzyme II receptor (ACE2) (2021). European Journal of Pharmacology, 891, p.173759. Mouffouk, C., Mouffouk, S., Mouffouk, S., Hambaba, L. and Haba, H.

Natural compounds flavonoids as modulators of inflammasomes in chronic diseases (2020) International Immunopharmacology, 84, p.106498.Owona, B.A., Abia, W.A. and Moundipa, P.F

Quercetin-3-O-β-D-Glucuronide Suppresses Lipopolysaccharide-Induced JNK and ERK Phosphorylation in LPS-Challenged RAW264.7 Cells (2016). Biomolecules & Therapeutics, 24(6), pp.610–615. Park, J.-Y., Lim, M.-S., Kim, S.-I., Lee, H.J., Kim, S.-S., Kwon, Y.-S. and Chun, W.

In silico pharmacokinetic and molecular docking studies of natural flavonoids and synthetic indole chalcones against essential proteins of SARS-CoV-2 (2020) European Journal of Pharmacology, 886, p.173448. Vijayakumar, B.G., Ramesh, D., Joji, A., Jayachandra prakasan, J. and Kannan, T.

The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases. BioMed Research International (2019), pp.1–11. Liu, W., Shi, L. and Li, S.

Mechanics Insights of Alpha-Lipoic Acid against Cardiovascular Diseases during COVID-19 Infection (2021). International Journal of Molecular Sciences, 22(15), p.7979. Rochette, L. and Ghibu, S.

Alpha lipoic acid as a potential treatment for COVID-19 – a hypothesis. (2021) Current Topics in Nutraceutical Research, 19(2), pp.172–175. ‌Sayiner, S., Sehirli, A.O. and Serakinci, N.

An essential role for the Zn 2+ transporter ZIP7 in B cell development. Nature Immunology ,(2019) 20(3), pp.350–361. ‌Anzilotti, C., Swan, D.J., Boisson, B., Deobagkar-Lele, M., Oliveira, C., Chabosseau, P., Engelhardt, K.R., Xu, X., Chen, R., Alvarez, L., Berlinguer-Palmini, R., Bull, K.R., Cawthorne, E., Cribbs, A.P., Crockford, T.L., Dang, T.S., Fearn, A., Fenech, E.J., de Jong, S.J. and Lagerholm, B.C.

Zinc sulfate in combination with a zinc ionophore may improve outcomes in hospitalized COVID-19 patients. (2020).  Journal of Medical Microbiology, Carlucci, P.M., Ahuja, T., Petrilli, C., Rajagopalan, H., Jones, S. and Rahimian, J.

Treatment of SARS-CoV-2 with high dose oral zinc salts: A report on four patients. International Journal of Infectious Diseases, (2020) 99, pp.307–309. Finzi, E

Zinc against COVID-19? Symptom surveillance and deficiency risk groups (2021). . PLOS Neglected Tropical Diseases, 15(1) Joachimiak, M.P.

Zinc in Human Health: Effect of Zinc on Immune Cells. Molecular Medicine, (2008). 14(5-6), pp.353–357. Prasad, A.S.

Zinc is an Antioxidant and Anti-Inflammatory Agent: Its Role in Human Health. Frontiers in Nutrition(2014). 1(14). Prasad, A.S.

Micronutrients in autoimmune diseases: possible therapeutic benefits of zinc and vitamin D (2020). The Journal of Nutritional Biochemistry, 77(12) Wessels, I. and Rink, L.

Leukocyte homing, fate, and function are controlled by retinoic acid. Physiological Reviews (2015). 95(1), pp.125–148. Guo, Y., Brown, C., Ortiz, C. and Noelle, R.J.

Vitamin A in resistance to and recovery from infection: relevance to SARS-CoV2. (2021)The British Journal of Nutrition, 126(11), pp.1–10. Stephensen, C.B. and Lietz, G.

Vitamin A Deficiency and the Lung. Nutrients (2018). 10(9), p.1132. Timoneda, J., Rodríguez-Fernández, L., Zaragozá, R., Marín, M., Cabezuelo, M., Torres, L., Viña, J. and Barber, T.