The severity and effects of COVID-19 infection have a wide range of symptoms many of which Doctors and researchers are still trying to fully understand. As this knowledge improves we are able to target specific mechanisms. Computer modelling, current knowledge of viral mechanisms and some early clinical trials have helped Doctors to appreciate which nutraceuticals and botanicals may help to support the immune system. We have been part of this conversation alongside a number of other Doctors.
Read our long form article Reducing COVID inflammation for the latest research and references to associated publications.
If you are not currently taking vitamin D3 or omega 3 we strongly recommend adding them to your daily routine, which is why they are included in these Essential Plus packs.
How nutraceuticals affect the immune response.
In many people COVID 19 creates a significant cytokine over-reaction or “storm” and it is this storm or “inflammasome” that is responsible for much of the damage. The most important being the “NLRP3 inflammasome-mediated IL-beta” production. Altering this response will alter the cytokine storm.
An enzyme called the main protease COVID 19 protein or “M Pro” is required for viral replication a number of therapeutics may affect this mechanism.
So in summary, reduce inflammation over-reaction and to do this healthy food, lifestyle and sleep are all equally essential. Reducing the viral load by blocking viral replication will decrease the severity and duration, at the same time boost both the adaptive and innate immune systems.
What combination of supplements help?
- Quercetin targets viral binding, replication and inflammation. Computational analysis has shown it can strongly bind the ACE2 receptor and disrupt Covid S spike protein entry into the cell. Furthermore, evidence shows quercetin blocks a protein releasing a protease called M Pro, which acts as a lock cutter that breaks open a molecular box containing Covid replication machinery that takes over the human cell. Finally, quercetin inhibits inflammatory molecules that drive immune cells into an inflammatory frenzy that damages delicate lung tissue such as interleukin 1, 6, 8, TNF-alpha and IFN gamma overproduction.
- Vitamin A is important for the growth and repair of lung tissues whilst also playing an important role in the immunity of mucus membranes. In the lungs and gut, Vitamin A is associated with sIgA levels. Covid reduces the absorption of vitamin A and needs to be boosted. Vitamin A smooths the levels of inflammatory molecules such as IL-6 and TNF-alpha by inhibiting the NF-kB inflammatory pathway. Studies show people who take vitamin A have reduced inflammatory markers such as CRP. Whilst also having a positive effect on innate immune cells and dendritic cells (the link between adaptive and innate branches of the immune system).
- N-acetyl cysteine (NAC) glutathione is a strong antioxidant currently being assessed in over a dozen clinical trials for efficacy in COVID. NAC is converted into Glutathione. A defensive mechanism is used when cells are under stress or under attack. Mechanisms include preventing damage from reactive oxygen species and ‘deactivating’ harmful compounds (through powerful detoxification pathways). Essential when dealing with Covid induced inflammation.
- Resveratrol is a powerful polyphenol antioxidant. Computer simulations along with biochemical assays show resveratrol could inhibit ACE2 and spike protein interactions which would decrease the virus ability to enter the cell. Evidence collected in vivo has shown it modulates cytokine and chemokine profile through the NF-kB pathway and inflammasomes.
- Zinc is essential for maintaining immune strength. Zinc deficiencies are correlated to disease susceptibility. Zinc-dependent enzymes are needed to assist T helper cell function and proliferation. As well as Macrophage function.
- Alpha-lipoic acid increases T cell activation in elderly populations. Reduces damage from ROS in mitochondria which may be responsible for some of the long COVID symptoms such as headaches. And a meta-analysis shows ALA supplementation reduces CRP levels as well as other inflammatory markers. The mechanism for which is thought to be modulating the NF-kB inflammatory pathway.
- Vitamin D3 and vitamin K2: Active form of vitamin D3 and MK7 natural K2 (most bioactive form). Vitamin D deficiency is very common. Affecting nearly 2 billion people worldwide multiple populations studies show low vitamin D levels and severity of covid are correlated. And it’s recommended high-risk groups take vitamin D supplementation. Past research on similar coronaviruses such as MERS-Covid has found Vitamin D induces antiviral effects and boost both innate and adaptive branches of the immune system. More recent studies indicate Vitamin D helps inhibit SARS-CoV-2 receptor binding. And regulate gene expression of cytokines such as TNF alpha and IL6 in air sack cells. Potentially mitigating harmful viral-induced inflammation
- Omega 3: high dose EPA and DHA: 1000mg of omega 3 of which 500mg EPA and 250mg DHA. Less aggressive inflammatory molecules are generated from omega 3 metabolism when compared to omega 6. But the western diet is so dominated by omega-6 your body has no choice but to produce these more inflammatory signaling molecules. Omega-3 supplementation encourages reduced inflammatory signaling, white blood cell migration and NF-kB inflammatory pathway activity whilst also promoting anti-inflammatory gene expression. Thereby helping preserve delicate lung tissue.
Immune support packs contain:
30 individual packs, each containing: Quercetin 400mg, NAC 600mg, Vitamin A 11,000 IU (300% NRV), Resveratrol 150mg, Elemental Zinc 50mg from 187mg zinc citrate (500% NRV), Alpha lipoic acid 300mg, Selenium 55 mcg (100% NRV), Vitamin C 90mg (110% NRV), Vitamin E from alpha tocopherol 30mg (250% NRV), Vitamin D3 4000 IU and K2 250 mcg, Omega 3 1000mg, of which 500mg EPA and 250mg DHA.
Take 1 pack per day, or 1-2 packs per day if symptoms are severe. In addition, high strength CoQ10 can also help to boost energy production and reduce incidence of headaches.
COVID 19: reducing COVID inflammation and long COVID symptoms – the latest research from leading Doctors made easy, November 2021