NMN Pure supplement | 500mg | 30 capsules | UK

NMN increases energy production in the cells and activates longevity pathways.

From our mid-twenties the energy batteries in our cells (mitochondria) start to drop off in function due to a lack of NAD+. As we reach middle age this reduces to around 50%. To restore that youthful vitality, it is essential to support and boost the production of NAD+. Low levels of NAD+ are intrinsically linked to the signs of ageing: mental decline, fatigue, poor glucose control and skin quality.

NMN is easily absorbed in the body. Studies have shown that taking NMN for 1 week will increase not only blood levels of NAD but also the NAD levels inside the cells and more importantly the mitochondria.

For most people taking it earlier in the day helps with energy. A Japanese study in subjects over 70 years old looking at sleep improvement found the best results for sleep correlated with the group taking NMN in late afternoon.

Energy- From our mid-twenties the energy batteries in our cells (mitochondria) start to drop off in function due to a lack of NAD+. As we reach middle age this reduces to around 50%. To restore that youthful vitality, it is essential to support and boost the production of NAD+. Low levels of NAD+ are intrinsically linked to the signs of ageing: mental decline, fatigue, poor glucose control and skin quality.

Brain power- A 2019 mice study showed that cerebral blood flow, which has an essential role in maintenance of healthy brain function, was improved by NMN. Blood flow is essential for a washout of harmful metabolites and to deliver oxygen and nutrients to the energy-hungry brain, given that the brain itself has limited energy reserves.

The study also noted that NMN activated sirtuin genes and increased biogenesis of mitochondria (the body’s energy producers). Both of these help to reduce the cognitive decline of old age.

Although NMN is found in foods such as broccoli, cucumber and avocado, it is present in very small amounts (around 0.25-1.9 mg per 100g). In order to get the same amount of NMN as one 500mg capsule you would need to consume a kilo of broccoli every day.

The best way to boost NMN / NAD+ is to take a supplement.

A 2019 study studied the effects of NMN on 10 healthy Japanese men. They showed that daily doses of up to 500mg are safe.

Many leading longevity experts such as Prof. David Sinclair take up to 1g per day.

Multiple studies have been done on humans with doses up to 1200mg. None of these have noted any side effects.

NMN is recognised as an active product that is non-pharmaceutical as it exists in nature and is  generally recognised as safe (“GRAS”).

We recommend 1-2 capsules per day.

To boost the longevity effects of NMN and improve activation of the key anti-ageing pathways see our blogs on NMN and on Longevity.

We think the best Longevity supplements are as below. To make life easy we have put together in our Longevity pack.

1. NMN The humanpeople NMN is 99.5% pure B-nicotinamide mononucleotide, which is highly absorbable in the gut. It increases energy production, increases AMPK and activates sirtuins.
2. Quercetin increases NAD+ levels through inhibition of CD38, the enzyme that breaks down NAD+, thereby boosting the effects of NMN
3. Resveratrol works by activating sirtuin pathways. Trans-resveratrol is the most active form and works synergistically with NMN.
4. Coenzyme Q10 is a commonly used cofactor as it is as essential mitochondrial electron transporter as well as acting as an antioxidant. It delays brain atrophy and a blinded study showed that within 8 days the participants on CoQ10 were able to cycle further with lower fatigue. Synthesis of CoQ10 is dependent on vitamins B2 (riboflavin) and vitamins B6 (pyridoxal-phosphate), folate (vitamin B9), pantothenic acid (vitamin B5), niacin (vitamin B3) and vitamin C.
5. D3 and K2
6. B complex methylated active form

To increase NAD levels and activate the important sirtuin pathways it is beneficial to take NMN rather than niacin.

The reason for this is that nicotinamide NAM is a step further back in the process. It needs to be converted into NMN and then NAD+.

Taking NAM will inhibit the sirtuins. When sirtuin dependent deacetylase are activated by NAD+ the NAD+ is then converted into NAM. If there is too much NAM present it inhibits this step and you lose these benefits.

Vitamin B3, niacin and nicotinamide also cause flushing when taken at high doses.

Studies in mice have shown that NMN increases metabolism, which includes the breakdown of fat. A different study, however, which looked at menopausal women did not replicate this finding, but it is worth noting that the dosages used in this study (250mg per day) were low.

We believe that a daily NMN dosage of 500mg can help with weight loss. A recent SIRT diet, which uses diet and supplementation to activate a number of sirtuin pathways, has been shown to lead to weight loss. It is claimed that the musician Adele used this to lose over 50 pounds.

To be clear, we are not marketing NMN as a weight loss supplement. If weight loss is the goal, NMN should be taken in conjunction with a healthy diet and lifestyle regime.

They are different things. In short, NMN is the fastest way to boost NAD+. To boost NAD+ levels it needs to transported into the cells and then to the mitochondria.

To date no transporter has been found for NAD+. It appears that NAD+ has to be broken down into NMN or NR, transported into the cell and then converted back into NAD+.

In 2018 Grozio et al identified a transporter, Slc12a8, that moves NMN into the cell.

Each capsule is 500mg pure B-nicotinamide mononucelotide >99%.

There are no fillers or bulking agents.

Capsule: Veggie HPMC capsule.

1. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice Cell Metab 2016
2. NAD + Intermediates: The Biology and Therapeutic Potential of NMN and NR Cell Metab 2018
3. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic woman Science 2021
4. NAD+ metabolism and its roles in cellular processes during ageing Nature 2020
5. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds Nature 2016
6. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study J Int Soc Sports Nutrition 2021
7. Supplementation with NAD+ and Its Precursors to Prevent Cognitive Decline across Disease Contexts Nutrients August 2022
8. Mitochondrial Sirtuins in Skin and Skin Cancers Photochem Photobiol 2020
9. NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential nature 2020
10. Nicotinamide Mononucleotide Alleviates LPS-Induced Inflammation and Oxidative Stress via Decreasing COX-2 Expression in Macrophages Front Mol Biosci 2021
11. Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and womam Nature Aug 2022
12. Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility Endo 2021
13. Resveratrol Increases Intracellular NAD+ Levels Through Up regulation of The NAD+ Synthetic Enzyme Nicotinamide Mononucleotide Adenylyltransferase Nature Precedings 2010
14. Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38 Diabetes 2013
15. Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study Nutrients 2022