Nicotinamide Riboside (NR) | 500mg

Name: Nicotinamide Riboside (NR) | 500mg
Brand: Humanpeople
SKU: 1000100343
Price: 28.0 GBP
Availability: InStock

500mg

£28.00

Product variants

Antioxidant, heart health and longevity

Resveratrol contributes to the protection of cells from oxidative stress
Supports normal heart function
Activates anti-ageing pathways

Quantity

28 day supply (£1.00 / day)

ADD TO YOUR PERSONALISED STACK. BILLED AND DELIVERED EVERY 4 WEEKS.

Tax included. Shipping calculated at checkout.

View full details

Vegan

Vegetarian

Non-GMO

GMP

3rd Party Tested

No fillers

Gluten Free

The basics

How Nicotinamide Riboside (NR) works to quickly boost NAD.
Nicotinamide Riboside (NR) is a special form of vitamin B3 that serves as a direct precursor to Nicotinamide Adenine Dinucleotide (NAD+), a critical molecule that fuels mitochondrial energy production and supports cellular repair.
NR has been well studied for safety at levels up to 3000mg with no side effects. (2,4)
Why is NAD+ so important?
Boosts cellular metabolism – Powers ATP production for sustained energy. (1,3). Activates sirtuins – The longevity proteins responsible for DNA repair and anti-ageing benefits. (1,6). Protects against oxidative stress – Helps defend cells from ageing and metabolic decline. (1)
Unlike standard vitamin B3 (niacin or nicotinamide), NR is the most efficient at raising NAD+ levels, making it a superior choice for cellular rejuvenation and energy optimisation.
Recent studies published in Nature have also shown that it is beneficial for cognition and maintaining muscle mass in older men. (3,7)

The need to know

What are the benefits?

Antioxidant, heart health and longevity

Resveratrol contributes to the protection of cells from oxidative stress
Supports normal heart function
Activates anti-ageing pathways

The Science

A deep dive into NR and NAD+

1. NR is well absorbed and rapidly converted into NAD+ (5)
Studies show that oral supplementation of NR significantly increases NAD+ levels in human tissues, with increased levels in the blood withinn a week. (2,4)
This improves mitochondrial function, the batteries in our cells and overall cellular health. Compared to other precursors, NR is absorbed faster and more efficiently.

2.NR Activates sirtuins, key longevity eegulators
Sirtuins are a family of proteins that regulate DNA repair, inflammation, and metabolic health. NR supplementation has been shown to boost sirtuin activity, mimicking some benefits of calorie restriction and fasting. (1,6)

3. Supports brain health and cognitive function
NAD+ is essential for neuroprotection and synaptic function. Studies suggest that NR supplementation reduces neuroinflammation and supports cognitive resilience, which could be beneficial for age-related brain decline. (3)

4. NR Improves metabolic health and mitochondrial efficiency
Low NAD+ levels are associated with obesity, insulin resistance, and metabolic disorders. Human trials indicate that NR supplementation can enhance mitochondrial function and support healthy metabolism by improving insulin sensitivity and lipid balance. (1,6,7)

How will I know its working?

Improved energy, recovery and cognitive funciton

When to take it?

Take 1 capsule daily with food and water, unless specified otherwise on the sachet.

Ingredients

Active Ingredients	Amount Per Serving	% Daily Value
NR (99% Pure) Nicotinamide riboside chloride	500mg
Other ingredients: Hypromellose Vegetarian Capsule

Did you know?

Publications you might find interesting

Want to go a bit deeper?

The latest research

1. Cantó, C., et al. (2012). “The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.” Cell Metabolism. [DOI: 10.1016/j.cmet.2012.02.019]

2. Martens, C.R., Denman, B.A., Mazzo, M.R. et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 9, 1286 (2018). https://doi.org/10.1038/s41467-018-03421-7

3. Campbell JM. Supplementation with NAD+ and Its Precursors to Prevent Cognitive Decline across Disease Contexts. Nutrients. 2022 Aug 7;14(15):3231. doi: 10.3390/nu14153231. PMID: 35956406; PMCID: PMC9370773.

4. Berven, H., Kverneng, S., Sheard, E. et al. NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson’s disease. Nat Commun 14, 7793 (2023). https://doi.org/10.1038/s41467-023-43514-6

5. Trammell, S., Schmidt, M., Weidemann, B. et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun 7, 12948 (2016). https://doi.org/10.1038/ncomms12948

6. Kang, H., Park, YK. & Lee, JY. Nicotinamide riboside, an NAD+ precursor, attenuates inflammation and oxidative stress by activating sirtuin 1 in alcohol-stimulated macrophages. Lab Invest 101, 1225–1237 (2021). https://doi.org/10.1038/s41374-021-00599-1

7. Igarashi, M., Nakagawa-Nagahama, Y., Miura, M. et al. Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. npj Aging 8, 5 (2022). https://doi.org/10.1038/s41514-022-00084-z