Weight, fat resistance & metabolic hormone test (fasting)

Name: Weight, fat resistance & metabolic hormone test (fasting)
Brand: Humanpeople
SKU: 1000100222
Price: 250.0 GBP
Availability: InStock

Weight, fat resistance & metabolic hormone test (fasting)

£250.00

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- In clinic test only (fast before blood test)

- Understand fat loss resistance

- Unlock long-lasting weight loss, reduce muscle loss

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In clinic test only (over 100 locations)

You will receive an email within 24 hours to book a slot at one of 100 clinics nationwide.

Some of the hormone markers need to be analysed immediately and so are not suitable for home collection.

You will need to visit one of our partner Randox clinics. You can check locations below before purchasing, but you will need to wait for your confirmation before booking a time.

We will also check your height, weight and blood pressure as part of the health screen.

Clinic locations

Optimised weight loss: If you have insulin or fat resistance, your body will store fat and burn muscle.

If you go in to a calorie deficit whilst on a treatment like GLP-1 high insulin and insulin resistance at the fat cell level will "lock" fat in to your cells. Your body will therefore start to burn muscle leading to muscle NOT fat loss!!

Unlock your insights in to healthy weight loss. Get your insulin and fat resistance scores.

This advanced metabolic test measures advanced lipids like ApoB, ApoA, Apo C-II, Apo C-III, fasting insulin, and hormones including adiponectin, leptin, resistin and more (see below for full list.)

what is in this test

Advanced metabolic markers- insulin, glucose, hormones

Fasting glucose

Fasting glucose

This shows your blood sugar at the moment of the test. While it’s commonly used to check for diabetes, it often stays normal even when underlying issues are brewing.

Did you know? You can have regular blood sugar but still be insulin resistant, meaning your body is storing fat and burning muscle.

HbA1C (long-term glucose)

HbA1c

A measure of your average blood sugar over 2-3 months. It reflects long-term glucose control and is helpful to detect prediabetes or poor blood sugar handling.

Did you know? GLP-1s consistently lower HbA1c, and studies show they can even reverse prediabetes when combined with the right lifestyle changes.

Insulin (fasting)

Fasting insulin

This tells us how much insulin your body is producing to keep blood sugar stable. High fasting insulin is often the earliest sign of insulin resistance, even before glucose goes up.

Did you know? High insulin locks fat in and blocks fat burning, even if you’re eating fewer calories.

C-peptide (insulin production marker)

C-Peptide

When you body produces insulin it first makes a larger molecule called proinsulin. This is then split into two parts. That is split in to two parts to give insulin and c-peptide. C- peptide remains in the blood for 30 minutes whereas insulin only remains for 5-6 minutes and is used by each organs.

If the liver for example is insulin resistant it therefore uses up more insulin and the blood level make look normal. However, c-peptide will give a better indication of how much was produced.

Did you know? C-peptide stays stable in the blood longer than insulin and can reveal metabolic strain even when other numbers look fine.

Leptin- your fullness hormone

What it does: Leptin is the hormone that tells your brain you’ve had enough to eat. It’s made by your fat cells and helps regulate appetite, metabolism, and body weight.

Why it matters: In many people, especially women, leptin levels are high, but the brain stops responding. This is called leptin resistance.

That means:

You don’t feel full even when your body has enough energy
Your brain thinks you’re starving, slowing your metabolism.
Weight loss becomes harder, and rebound weight gain is more likely.

Linked to: Insulin resistance, belly fat, poor sleep, and chronic inflammation.

Did you know? Even slim people can have leptin resistance, especially if they’ve dieted frequently or have high insulin.

Why we test it: Knowing your leptin level helps us understand how your appetite signals are functioning and guides more innovative interventions, including GLP-1 use, supplements, or hormone balancing.

If you can become leptin sensitive, then your natural appetite suppression will kick in.

Adiponectin- the fat burning hormone

What it does: Adiponectin is made by your fat cells but unlike other fat-derived hormones, this one is anti-inflammatory and helps your body burn fat and use insulin more effectively.

Why it matters: Higher adiponectin = better metabolic health.

Low levels are often seen in:

Insulin resistance
Visceral fat (deep belly fat)
People who struggle to lose weight, even with dieting

Especially important for:

Women after menopause
People with prediabetes or metabolic syndrome
“Skinny fat” body types with hidden metabolic risk

Did you know? Thin people can still have low adiponectin and be at high risk for insulin resistance and inflammation.

Why we test it: Adiponectin gives insight into how well your fat cells are working. Low levels tell us your metabolism may be struggling to switch into fat-burning mode even if your weight seems normal.

Resistin- slows metabolism

What it does: Resistin is a hormone linked to inflammation and insulin resistance. It’s released by fat cells and immune cells and can interfere with your ability to burn fat and control blood sugar.

Why it matters: Higher resistin levels are often found in people with:

Belly fat or visceral fat
PCOS or metabolic syndrome
Stubborn weight gain despite diet changes

Especially important if:

You’ve been told your blood sugar is “borderline”
You’re gaining fat around your middle.
You feel inflamed, tired, or resistant to weight loss.

Did you know? High resistin levels can make other hormones like leptin and insulin stop working properly, leading to a blocked metabolism.

Why we test it: Resistin acts like a brake on your metabolic system. Knowing your level can help target the real reason your body isn’t responding to standard weight loss advice.

NEFA (non-esterified fatty acids)- fat resistance marker

What it does: NEFAs are fatty acids released from fat cells into the bloodstream. They’re meant to provide energy, but when they’re too high, it signals that your fat cells are no longer responding correctly to insulin.

Why it matters: Elevated NEFA levels mean your body is in a state of fat resistance where fat is being released unpredictably, but not efficiently used for energy.

This can lead to:

Insulin resistance
Fatty liver
Cravings and poor energy balance
Reduced response to weight loss efforts

Especially important for:

People who struggle to lose fat even in a calorie deficit
Those with high fasting insulin or triglycerides
“Skinny fat” or metabolically unhealthy normal-weight individuals

Did you know? NEFA is one of the earliest signs that your fat metabolism is dysfunctional even before weight or glucose change.

Why we test it: NEFA helps us understand how your fat cells are behaving behind the scenes whether they’re working with you or against you. It’s a key marker for identifying early-stage fat resistance and metabolic stress.

what is in this test

Advanced metabolic markers- lipids

Apoliprotein B

Each LDL particle, which carries cholesterol, has one ApoB protein. Measuring ApoB gives a true count of LDL particles in your blood. Since smaller LDL particles are more harmful than larger ones, knowing the number of particles can help assess cardiovascular risk more accurately than just measuring LDL cholesterol alone.

Importance: ApoB is found in LDL (low-density lipoprotein) and VLDL (very-low-density lipoprotein) cholesterol. It's essential for the transport and distribution of cholesterol. Since LDL is often labeled as "bad" cholesterol, ApoB serves as a marker for atherogenic particles – those that contribute to plaque buildup in arteries.

Did you know? A normal LDL with a high ApoB can still mean increased risk — this test picks up what traditional cholesterol panels miss.

Insights: Elevated levels of ApoB are associated with an increased risk of cardiovascular disease, as they indicate a higher quantity of LDL particles, which can lead to plaque formation and arterial blockages.

Apolipoprotein A-I (ApoA1)

ApoA is a component of HDL, the 'good' cholesterol. It helps remove cholesterol from the body. High levels of ApoA indicate a healthy cholesterol transport system and a lower risk of heart disease.

Did you know? People with higher ApoA1 live longer and have a lower risk of heart attacks even if their LDL is slightly raised.

Importance: ApoA is a primary protein component of HDL (high-density lipoprotein) cholesterol, often referred to as "good" cholesterol. It plays a critical role in lipid metabolism, particularly in the removal of cholesterol from cells and its transport back to the liver for excretion.
Insights: Higher levels of ApoA are usually indicative of a healthier lipid profile and a lower risk of cardiovascular disease. This is because ApoA aids in the process of reverse cholesterol transport, which is protective against the development of atherosclerosis.

ApoB/ApoA1 Ratio

ApoB/ApoA1 Ratio:This ratio compares the amount of ApoB (bad cholesterol marker) to ApoA1 (good cholesterol marker). A higher ratio means there's more bad cholesterol relative to good cholesterol, indicating a greater risk for heart problems.Importance: This ratio compares the levels of ApoB and ApoA1, providing a balance between harmful and protective lipoproteins.

Did you know? This ratio outperforms traditional cholesterol in predicting stroke and heart attack risk, especially in people who look “healthy” on basic tests.

Insights: A higher ApoB/ApoA1 ratio is indicative of a higher concentration of atherogenic lipoproteins relative to protective ones, suggesting a heightened risk for atherosclerosis and cardiovascular diseases. It's a more comprehensive measure than looking at LDL or HDL alone.

Apo C-II, Apo C-III, ApoE

Apolipoprotein C-II (ApoC-II)

ApoC-II helps activate enzymes that break down triglycerides, the fats in your blood. If your ApoC-II is too low, your body may struggle to clear fats properly, which can lead to elevated triglycerides and fat storage.

Did you know? ApoC-II is like an “on switch” for fat breakdown after meals. If it’s low, your blood can stay fatty for longer.

Apolipoprotein C-III (ApoC-III)

The flip side of C-II ApoC-III slows down fat breakdown. High levels are linked to higher triglycerides, inflammation, and insulin resistance.

Did you know? ApoC-III is strongly linked to fatty liver and pre-diabetes, and is being targeted by new drugs for metabolic disease.

Apolipoprotein E (ApoE)

ApoE helps clear cholesterol and fats from your blood and also plays a role in brain health. There are three main types: E2, E3 and E4. Some people with the E4 version may have higher cholesterol and an increased risk of Alzheimer’s.

Did you know? Your ApoE type can influence how you respond to saturated fats, and may also affect memory and brain ageing.

Lipoprotein (a) [Lp(a)]

Lp(a) is a type of cholesterol particle similar to LDL but with an added protein that increases the risk of heart disease. High levels of Lp(a) are mainly determined by genetics and are a strong indicator of heart disease risk.

Importance: Lp(a) is a variant of LDL cholesterol but with an additional protein, apolipoprotein(a). It's an independent risk factor for cardiovascular disease and is largely genetically determined.
Insights: Elevated levels of Lp(a) are concerning as they can contribute to the development of atherosclerosis, increasing the risk of heart attacks and strokes. Unlike other lipid markers, Lp(a) levels are not significantly affected by lifestyle changes and are more challenging to manage.

Total Cholesterol, LDL, HDL, Triglycerides

Total cholesterol

The overall amount of cholesterol in your blood. It gives a big-picture view but doesn’t show the full story or give a good insight in to cardiovascular issues we look deeper to understand your real risk.

Did you know? High cholesterol isn’t just caused by fat sugar and processed carbs can raise it too by increasing triglyceride-rich lipoproteins.

LDL Cholesterol (the “bad” one)

High levels of LDL can lead to cholesterol build-up in your arteries. It’s one of the key markers we track for heart and metabolic health. However, not all LDL is created equal there are larger and smaller LDL’s that is were some of the more advanced markers give us more accurate information.

Did you know? Stress and chronic inflammation can raise LDL even if your diet is clean.

HDL Cholesterol (the “good” one)

HDL helps clear out excess cholesterol. Higher HDL levels are linked to better heart health and can improve with the right nutrition and activity.

Did you know? Eating more healthy fats (like olive oil or avocado) can help raise HDL.

Triglycerides

These are fats stored in your blood after eating. High levels are common in insulin resistance and can increase your risk of heart disease. GLP-1s are especially effective at reducing these.

Did you know? High triglycerides are one of the earliest warning signs of metabolic dysfunction — often before blood sugar rises.

Total Cholesterol: HDL Ratio and Triglyceride: HDL Ratio

These ratios compare total cholesterol and triglycerides to HDL (good) cholesterol. Lower ratios are better, indicating a lower risk of heart disease.

Total Cholesterol / HDL Ratio

A powerful marker that shows the balance between good and bad cholesterol. A lower ratio = lower heart risk.

Did you know? Even with “normal” cholesterol, a high ratio still increases risk this is why ratios matter more than total numbers.

Small dense LDL cholesterol

Small LDL Cholesterol

Smaller LDL particles are more likely to cause damage inside blood vessels. This test helps detect a hidden risk not seen in standard cholesterol panels.

Did you know? You can have “normal” LDL but still high small, dense LDL, which is much more dangerous.

Manage your cholesterol risk naturally

Why it matters

Insulin resitance
- This is when your body has a constant message to store energy as fat regardless of what you eat.
- Insulin resistance is a key step in weight gain and metabolic issues.
Fat resistance
- By calculating the fat resistance score (adipo-IR) we can calculate how resistant your cells are to releasing energy, even during fasting or calorie restriction.
- Unlocking fat resistance is the key to healthy weight loss and a reduction in muscle loss.
Lipoprotein imbalances and hidden inflammation
- Lipoprotein imbalances – especially ApoB, ApoC-III, and Lp(a), which are better predictors of cardiovascular risk than LDL alone
- hsCRP a silent driver of weight gain, heart disease and ageing. Visceral fat (belly fat) is a key driver of inflammation.

What are the key ratios

HOMA-IR standard insulin resistance score (blood and liver)
HOMA-IR is a well-established score that uses fasting glucose and insulin to estimate how resistant your body is to insulin, a key early sign of metabolic dysfunction. It’s useful, but it doesn’t always detect issues at the fat cell level, where many people experience “hidden” resistance that blocks fat burning, even with a good diet.
That’s why our panel goes further, looking at additional metabolic and hormone markers that reveal what’s happening behind the scenes. This helps us identify fat resistance, belly fat–driven inflammation, and the root cause of weight plateaus, even when HOMA-IR looks normal.
Fat cell insulin resistance
Some types of insulin resistance don’t show up clearly in traditional blood sugar tests. That’s because the issue isn’t just how your cells respond to insulin, it’s how your fat cells handle energy. When fat cells become resistant to insulin, they stop releasing energy properly and start leaking fats into the bloodstream. This creates a hidden form of resistance we call fat lock-in, and it makes losing weight much harder, even with reduced calories.
Our test looks at deeper signals to detect this pattern, helping us identify why fat won’t budge even when the basics look fine.
Visceral (belly fat) resistance and inflammation
Chronic low-grade inflammation, especially from belly fa,t can interfere with how your body uses insulin, even if your glucose or insulin levels seem normal. This inflammatory resistance isn’t always obvious, but it’s one of the key reasons people plateau on diets or experience poor results from GLP-1 medications.
By measuring specific hormone patterns and inflammatory markers, our panel reveals when inflammation is silently working against your metabolism, and helps us target the fix.

Track and measure

Mobile phone showing a humanpeople dashboard

Personal dashboard

Your results will be uploaded to your personal secure dashboard.

You can track progress over time and optimise your essential nutrient status.

Personal recommendations

The metabolic health assessment is a simpel report. The test does not include Dr interpretation of the results.

frequently asked questions

FAQ

Does the blood test hurt?

The blood test is performed by a phlebotomist at a clinc.

When will I get my results?

Results are usually back within 5 working days, but we can often do a lot quicker than that.

Explanation of results

Your results will have some simple explanations. If you are part of a special metabolic health programme then your Doctor may go through these in more detail

Is humanpeople a registered and regulated company?

Yes. Unlike a lot of other blood testing companies in the UK. humanpeople is registered with the CQC as a health and diagnostic company.

That means we are reviewed and must follow strict UK guidelines on giving results and advice.

The labs. we use are also regulated by CQC.

You can check out our registration details here.

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Weight, fat resistance & metabolic hormone test (fasting)