Berberine is a naturally occurring alkaloid compound in various plants, including the barberry shrub.
It is a powerful herbal medicine used by Functional medicine practitioners, most notably for its potential role in improving gut health.
It is also a powerful tool in managing blood sugar levels and promoting cardiovascular health.
The need to know
What are the benefits?
Gut health & sugar stabiliser
Lowers blood sugar comparable to metformin
Weight loss and improved gut health, reduces cholesterol
Exercise performance and longevity
Berberine has been shown to activate an enzyme called AMP-activated protein kinase (AMPK) inside body cells. This enzyme is sometimes referred to as a "metabolic master switch" because it plays an essential role in regulating metabolism. Through this activation, berberine may help improve insulin sensitivity, promote glucose uptake in cells, and reduce glucose production in the liver.
In terms of cardiovascular benefits, berberine's cholesterol-lowering effects are believed to be mediated through its impact on the gut microbiota and its ability to reduce the absorption of cholesterol from the gut.
Berberine's antimicrobial action arises from its ability to interfere with the adhesion of pathogens to host cells, disrupting their biofilm formation and interrupting their cellular communication.
How will I know its working?
Successful use of berberine might manifest as more stabilized blood sugar levels, reduced cholesterol levels, and improved overall cardiovascular health. Additionally, those taking berberine for its antimicrobial properties might note a reduction in infections or related symptoms.
When to take it?
Take 1-2 capsules daily with food and water, unless specified otherwise on the sachet.
Serving Size 1 Vegetarian Capsule
Per Serving% Daily
* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value not established.
Brown Rice Flour, Gelatine
Did you know?
Ancient Roots: Berberine's use as a medicinal herb can be traced back over 3,000 years in traditional Chinese and Ayurvedic medicine.
Diverse Plant Origins: Berberine is not exclusive to one plant. It's extracted from several plants, including the barberry shrub, goldenseal, Oregon grape, and tree turmeric.
Broad Medical Reach: Beyond its metabolic and cardiovascular impacts, berberine has been researched for potential benefits ranging from anti-inflammatory effects to potential anti-cancer properties.
Publications you might find interesting
Want to go a bit deeper?
The latest research
1. Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., ... & Zhang, J. H. (2010). Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism, 59(2), 285-292.
2. Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., ... & Jiang, J. D. (2004). Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nature Medicine, 10(12), 1344-1351.
3. Wu, Y. C., Hsieh, C. L., Jiang, Y. H., Lin, W. C., Wu, Y. H., & Cheng, J. T. (2007). Berberine reduces leukocyte adhesion to LPS-stimulated endothelial cells and VCAM-1 expression both in vivo and in vitro. International Journal of Immunopathology and Pharmacology, 20(3), 447-457.
4. Wang, Q., Zhang, M., Liang, B., Shirwany, N., Zhu, Y., & Zou, M. H. (2011). Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2. PloS One, 6(9), e25436.
5. Ilyas Z, Perna S, Al-Thawadi S, et al. The effect of Berberine on weight loss in order to prevent obesity: A systematic review. Biomed Pharmacother. 2020;127:110137. doi:10.1016/j.biopha.2020.110137
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