Berberine

Name: Berberine
Brand: Humanpeople
SKU: 1000100083
Price: 6.21 GBP
Availability: InStock

Berberine

500mg

£6.21

28 day supply (£0.22 / day)

£6.21

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Product variants

• Regulates blood sugar

• Lowers cholesterol

• Acts as a natural antimicrobial against unwanted pathogens

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The basics

Berberine is a naturally occurring alkaloid compound in various plants, including the barberry shrub.

It is a powerful herbal medicine used by Functional medicine practitioners, most notably for its potential role in improving gut health.
It is also a powerful tool in managing blood sugar levels and promoting cardiovascular health.

The need to know

What are the benefits?

Gut health & sugar stabiliser

Lowers blood sugar comparable to metformin
Weight loss and improved gut health, reduces cholesterol
Exercise performance and longevity

The Science

Berberine has been shown to activate an enzyme called AMP-activated protein kinase (AMPK) inside body cells. This enzyme is sometimes referred to as a "metabolic master switch" because it plays an essential role in regulating metabolism. Through this activation, berberine may help improve insulin sensitivity, promote glucose uptake in cells, and reduce glucose production in the liver.

In terms of cardiovascular benefits, berberine's cholesterol-lowering effects are believed to be mediated through its impact on the gut microbiota and its ability to reduce the absorption of cholesterol from the gut.

Berberine's antimicrobial action arises from its ability to interfere with the adhesion of pathogens to host cells, disrupting their biofilm formation and interrupting their cellular communication.

How will I know its working?

Successful use of berberine might manifest as more stabilized blood sugar levels, reduced cholesterol levels, and improved overall cardiovascular health. Additionally, those taking berberine for its antimicrobial properties might note a reduction in infections or related symptoms.

When to take it?

Take 1 capsule daily with food and water, unless specified otherwise on the sachet.

Ingredients

Supplement Facts

Ingredient Amount
Per Serving % Daily
Value

Berberine 500mg
†

* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value not established.

Vegetarian Capsule

Did you know?

Publications you might find interesting

Want to go a bit deeper?

The latest research

1. Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., ... & Zhang, J. H. (2010). Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism, 59(2), 285-292.

2. Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., ... & Jiang, J. D. (2004). Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nature Medicine, 10(12), 1344-1351.

3. Wu, Y. C., Hsieh, C. L., Jiang, Y. H., Lin, W. C., Wu, Y. H., & Cheng, J. T. (2007). Berberine reduces leukocyte adhesion to LPS-stimulated endothelial cells and VCAM-1 expression both in vivo and in vitro. International Journal of Immunopathology and Pharmacology, 20(3), 447-457.

4. Wang, Q., Zhang, M., Liang, B., Shirwany, N., Zhu, Y., & Zou, M. H. (2011). Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2. PloS One, 6(9), e25436.

5. Ilyas Z, Perna S, Al-Thawadi S, et al. The effect of Berberine on weight loss in order to prevent obesity: A systematic review. Biomed Pharmacother. 2020;127:110137. doi:10.1016/j.biopha.2020.110137