Calcium-D-glucarate is a compound that has its roots deeply embedded in nature. As the calcium salt form of D-glucaric acid, it is naturally present in various fruits and vegetables, with notable concentrations in grapefruit, apples, and broccoli.
Beyond just being a component of our daily dietary intake, Calcium-D-glucarate boasts a suite of health benefits. Notably, its prominence in detoxification pathways, fundamental to maintaining homeostasis and proper physiological function in our bodies, sets it apart. Through its function, it manages a balancing act, especially in the delicate hormonal ballet, ensuring that excessive estrogen, which could be detrimental, is efficiently processed and excreted.
It is also efficient at blocking the re-uptake of exhausted oestrogen metabolites from the gut by blocking the beta-glucuronidase enzyme produced by some bacteria.
The need to know
What are the benefits?
Supports detoxification and excretion of by-products
May help prevent certain types of cancer
Calcium-D-glucarate operates through a scientifically fascinating mechanism termed "glucuronidation." ds:
In the liver, glucuronic acid binds with toxins and certain hormones, including excess estrogens. This process essentially tags them for excretion, making them more water-soluble and thus easier to be eliminated from the body through urine or bile.
However, certain bacteria in the gut can throw a wrench in the works. They produce an enzyme called beta-glucuronidase, which can sever the bond between glucuronic acid and the toxin or hormone. When this happens, instead of being excreted, these potentially harmful compounds can be reabsorbed into the bloodstream.
Calcium-D-glucarate acts as a beta-glucuronidase inhibitor. By tempering the activity of this enzyme, Calcium-D-glucarate ensures that the body's natural detoxification processes aren't reversed. The result? Toxins and excess hormones get effectively flushed out of the system, reducing their potential harmful impacts. This mechanism is particularly vital when considering oestrogen's role. While necessary for various physiological processes, an overabundance of this hormone, or its metabolism into harmful byproducts, has been linked to a variety of health issues, including certain cancers. Calcium-D-glucarate, by aiding in the elimination of excess estrogen, can thus play a pivotal role in maintaining hormonal balance and health.
How will I know its working?
When taking this supplement, you may notice:
Improved digestive health, with fewer instances of bloating or discomfort.
A feeling of increased overall wellness and vitality, potentially due to reduced toxin levels.
Improvements in hormonal balance or cardiovascular metrics.
When to take it?
Take 1 capsule daily with food and water, unless specified otherwise on the sachet.
Per Serving% Daily
Calcium D Glucarate
500mg (60mg elemental)
* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value not established.
Cellulose, Stearic Acid
Did you know?
Calcium-D-glucarate is found in the highest concentrations in grapefruits, traditionally associated with various health benefits.
The detoxification pathway facilitated by Calcium-D-glucarate, glucuronidation, is one of the liver's significant phase II detoxification routes.
Research hints that Calcium-D-glucarate might play a role in cancer prevention, although more studies are required to ascertain this benefit.
Publications you might find interesting
Want to go a bit deeper?
The latest research
1. Heerdt, A. S., et al. (1995). Calcium glucarate as a chemopreventive agent in breast cancer. Israel journal of medical sciences, 31(2-3), 101-105.
2. Walaszek, Z., et al. (1997). Dietary glucarate-mediated reduction of sensitivity of murine strains to chemical carcinogenesis. Cancer letters, 115(1), 15-19.
3.Walaszek, Z. (1990). Potential use of D-glucaric acid derivatives in cancer prevention. Cancer letters, 54(1-2), 1-8.
4. Abou-Zeid, L. A., et al. (2011). D-glucarate effects on inflammation and metastasis of Ehrlich ascites carcinoma in female mice. Nutrition and cancer, 63(6), 862-870.
5. Kohlmeier, M., et al. (1993). Adipose tissue level of calcium-D-glucarate has an inverse association with breast cancer risk. Cancer epidemiology, biomarkers & prevention, 2(4), 299-303.
Gain access to your own data driven dashboard, health reports and personalised supplement plans.