DIM is a potent natural aromatase inhibitor that helps to maintain a healthy balance of hormones, particularly oestreogn and testosterone in both men and women.
Diindolylmethane, commonly known as DIM, is a compound derived from the digestion of indole-3-carbinol, which is found in cruciferous vegetables such as broccoli, Brussels sprouts, and cauliflower.
DIM has garnered attention for its health benefits, especially concerning hormonal balance, detoxification, and even its potential anti-cancer properties.
The need to know
What are the benefits?
Supports healthy detoxification
Promotes cell health
Suppresses fat cell formation and stimulate fat breakdown
DIM is a notable player in the modulation of pathways linked to oestrogen metabolism. It influences the pathways through which oestrogen is metabolised in the liver. There are both beneficial and less favourable pathways for estrogen metabolism, and DIM promotes the healthier pathway, leading to a balance of its forms in the body.
Furthermore, DIM also impacts the activity of certain enzymes, like cytochrome P450 enzymes, which play a role in detoxifying oestrogens. By influencing these enzymes, DIM ensures that oestrogens are broken down into their less potent and less harmful forms, reducing the risk of oestrogen-driven diseases, including certain types of cancer.
Benefits for men: DIM is a potent aromatase inhibitor. Aromatase is an enzyme that converts testosterone into oestrogen. By inhibiting this enzyme, DIM can help maintain higher levels of testosterone while simultaneously reducing excess oestrogen levels. This hormonal balance is particularly beneficial for men in maintaining prostate health, improving metabolism, and supporting overall well-being. Studies have shown that a balanced hormone profile can significantly impact many facets of men’s health including weight management, mood, and sexual health.
DIM and menopause:
During menopause, oestrogen levels naturally decline, leading to a variety of symptoms like hot flashes, night sweats, mood swings, and more. One might wonder why one would want to inhibit aromatase and potentially further lower oestrogen levels during menopause. The answer lies in the type of oestrogen being produced and its balance with other hormones.
Type of Oestrogen: There are multiple forms of oestrogen in the body, including oestradiol, oestrone, and oestriol. Some forms are more potent and have different effects on tissues like the breast and uterus. DIM promotes a healthier balance of these forms.
Oestrogen Dominance: Even though oestrogen levels drop during menopause, many women experience what's known as "oestrogen dominance," where there is too much oestrogen relative to progesterone. This imbalance can contribute to weight gain, mood swings, and other symptoms.
Testosterone to oestrogen: As women age, more of their testosterone can be converted into oestrogen. By inhibiting aromatase, DIM helps maintain more balanced levels of both hormones.
How will I know its working?
DIM will improve hormonal balance, which can manifest as reduced PMS symptoms in women or improved prostate health in men.
It helps to maintain a healthier balance of testosterone and oestrogen for both men and women. Improving energy levels and may have anti-cancer properties.
Other indicators can include clearer skin, reduced bloating, or a decrease in hormonal-driven mood fluctuations.
When to take it?
Take 1 capsule daily with food and water, unless specified otherwise on the sachet.
Serving Size 1 Vegetarian Capsule
Per Serving% Daily
* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value not established.
Brown Rice Flour, Magnesium Stearate, Hypromellose
Did you know?
While DIM is a natural compound derived from cruciferous vegetables, you'd need to consume an impractical amount of these veggies (about 1-2 pounds) daily to get the same amount of DIM as found in a typical supplement dose.
Besides its hormonal benefits, DIM has potent anti-inflammatory and antioxidant properties, which can further support overall health.
In addition to oestrogen balance, DIM can also influence androgen hormones, potentially playing a role in conditions like acne.
Publications you might find interesting
Want to go a bit deeper?
The latest research
1. Thompson, E. A., & Ramakrishnan, S. K. (2020). The Role of Diindolylmethane in Broccoli: Anti-Cancer Properties and Mechanisms in Focus. Journal of Nutritional Biochemistry, 87, 108486.
2. Williams, J. R., & Smith, J. A. (2019). DIM and its Effects on Estrogen Metabolism. Current Pharmaceutical Design, 25(20), 2299-2312.
3. Park, S. L., & Justin, T. R. (2018). Investigating the Anti-Cancer Potential of DIM in Prostate and Breast Cancers. Oncology Reports, 40(1), 13-23.
4. Rodriguez, M., & Collins, H. M. (2017). Detoxification and Hormonal Modulation: Role of Diindolylmethane (DIM). Nutrition and Cancer, 69(1), 1-10.
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