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Testosterone is a powerful hormone that drives numerous vital functions. Yes, it is vital for muscle and strength but it is a lot more than that it helps with sex drive/ libido, it makes effort enjoyable, it helps with energy, fat distribution, bone health, red blood cells and more.
During the peri-menopause oestrogen, progesterone and testoserone levels all decline.
This decline tends to keep the balance between all three. However, if you are on HRT oestrogen and progesterone are markedly raised in comparison testosterone affecting the natural balance.
Dr Geoff Mullan MBBS, BSc. MRCS, DO-HNS, AFMCP
Chief Medical Director
It tells us the total amount of testosterone being produced.
It does not tell us how much active testosterone is present.
We need to look at other markers to calculate the active level.
Sex Hormone-Binding Globulin (SHBG) is a key protein in the body that plays a crucial role in regulating the availability of sex hormones, particularly testosterone and oestrogen.
When it is very high less active testosterone is available. Instead of increasing testosterone it may be beneficial to reduce SHBG levels instead for example.
Function:
Regulation of Hormone Activity:
Factors Affecting SHBG Levels:
This is the other protein in the blood that binds testosterone and is used to calculate an accurate active tesosterone level.
In premenopausal women, normal total testosterone levels typically range from about 0.3 to 2.4 nmol/L.
Testosterone is produced primarily by the ovaries and the adrenal glands.
Oestrogen levels fluctuate throughout the menstrual cycle. The most potent estrogen, oestradiol, varies from approximately 0.1 to 0.6 nmol/L during the menstrual cycle, peaking just before ovulation.
The units they are normally measured in are different
To compare estrogen and testosterone levels, you would ideally want them in comparable units. Since 0estrogen is measured in pmol/L and testosterone in nmol/L, you can convert one to the other's units for direct comparison. Conversion: Testosterone (pmol/L) = Testosterone (nmol/L) × 1000.
Exercise, Especially Strength Training: high-intensity interval training (HIIT), can boost testosterone levels.
Healthy Diet: A balanced diet rich in protein, healthy fats, and essential nutrients supports testosterone production.
Adequate Sleep: Quality sleep is crucial for testosterone production.
Stress Reduction: Chronic stress elevates cortisol levels and reduces testosterone production.
Often HRT issues are put down to oestrogen replacement being low. It's difficult to gauge from a blood test as the variation in receptor sensitivity can be significant.
Often oestrogen is increased, making the balance worse when actually what is needed is a small amount of testosterone.
Testosterone Replacement Therapy (TRT):
TRT is used to restore testosterone levels in men with low testosterone (hypogonadism).
It reduces natural production so should only be considered after trying natural methods.
Forms: TRT can be administered via injections, transdermal patches, gels, or subcutaneous pellets.
Monitoring and Risks: Regular monitoring is necessary to manage potential side effects, such as increased red blood cell count and prostate health issues.
Although testosterone replacement is common in the US it is less so in the UK. The only indication being low lidbio.
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Your results will be integrated with your health assessment.
One of our medical team will review these and make nutrition, lifestyle and supplement recommendations.
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