NR pure | 500mg | 30 capsules

Each capsule contains 500mg of high-purity nicotinamide riboside chloride (NR) with 99.5% purity - it’s one of the most refined forms of NR available. NR is a scientifically recognised derivative of vitamin B3 and is widely studied for its ability to raise NAD+ levels safely and effectively.

Our NR capsules are free from fillers, additives, and bulking agents. They are non-GMO, suitable for both vegans and vegetarians, and manufactured to the highest quality standards.

Each jar contains 30 capsules - a full month’s supply when taken daily. If you include NR in your 4-week personalised supplement pack, you'll receive 28 capsules to align with your monthly cycle.

NR can be taken at any time of day to support energy, focus, and resilience, depending on your individual goals. Many people take it in the morning to enhance mental clarity and physical stamina throughout the day. Athletes often report feeling a noticeable boost in energy when NR is taken 20-30 minutes before exercise, aligning with research that shows NR enters the bloodstream within 5-10 minutes of ingestion.

Because NR increases NAD+ levels in the brain, it also supports cognitive performance including sharper focus, improved memory, and mental stamina. For those looking to optimise recovery and sleep, taking NR in the late afternoon may help. Some studies suggest that this timing can support the body’s natural repair processes and improve sleep quality by aligning with circadian rhythms.

Whether you’re looking to perform better, think clearer, or rest deeper, NR fits flexibly into your daily routine.

NR (Nicotinamide Riboside) is one of the most effective ways to increase NAD+ levels, which naturally decline with age. This has a wide-reaching effect across multiple systems in the body from energy production and brain function to sleep quality, metabolic health and longevity.

NR has been shown to increase NAD levels in line with NMN. In the UK NR is fully compliant and legal.

One of the most immediate benefits of NR is increased energy. NAD+ is essential for mitochondrial function, the process that powers every cell in the body. As NAD+ levels drop with age, so does our ability to produce energy. Clinical research has shown that restoring NAD+ through NR supplementation can help reverse this. In a 2021 randomised controlled trial, trained runners who took NR daily and followed a regular training schedule for six weeks showed a significant improvement in aerobic capacity compared to those on a placebo.

NR also supports cognitive performance and long-term brain health. A 2019 preclinical study found that boosting NAD+ levels improved cerebral blood flow, which plays a vital role in clearing harmful metabolites and delivering nutrients and oxygen to the brain. The same study showed that NAD+ activated sirtuin genes and stimulated mitochondrial biogenesis two mechanisms linked to slowing age-related cognitive decline.

NR’s effects extend to healthy ageing and longevity. By supporting DNA repair pathways and reducing oxidative stress, it can help delay or reduce the impact of age-related diseases, including diabetes, cardiovascular conditions, and neurodegeneration. Regular NR supplementation may contribute to better metabolic control and increased resilience as we age.

Sleep is another area where NR shows benefit. A Japanese study published in 2022 assessed the sleep quality of 108 older adults and found significant improvements in both sleep duration and sleep quality when NR was taken in the afternoon. Participants also reported reduced fatigue and better lower limb strength, markers of improved recovery and daytime function.

Finally, NR plays a direct role in DNA repair. By activating sirtuins, the proteins responsible for maintaining DNA integrity, NR helps your cells function more like they did when you were younger. This is vital for preventing cellular senescence when cells lose their ability to divide and contribute to skin ageing, cognitive decline, and loss of organ function. Supporting DNA repair at the cellular level is one of the most important steps in healthy ageing.

While small amounts of NAD+ precursors like NMN and NR can be found in foods such as broccoli, cucumber, and avocado, the concentrations are extremely low typically around 0.25 to 1.9 mg per 100g. To get the equivalent of a single 500mg capsule of NR, you’d need to eat over a kilo of broccoli every day, which simply isn’t practical or sustainable.

Because NAD+ levels naturally decline with age, and dietary sources are limited, the most effective and research-backed way to restore NAD+ is through supplementation with pure nicotinamide riboside. NR is highly bioavailable, well-tolerated, and rapidly absorbed making it the most efficient method to consistently and safely boost NAD+ levels and support long-term health.

Yes, NR (Nicotinamide Riboside) is considered safe and well-tolerated in humans, with multiple clinical studies confirming its safety profile at a range of doses. Research has shown that daily supplementation with up to 1000mg of NR is safe, with no serious side effects reported.

Many experts in the field of ageing and longevity, including Professor David Sinclair and others, have publicly discussed the use of NAD+ precursors like NR to support long-term health. NR is a naturally occurring compound and a form of vitamin B3, which the body converts efficiently into NAD+.

Nicotinamide Riboside is also recognised as “Generally Regarded As Safe” (GRAS), meaning it is a non-pharmaceutical active ingredient that exists in nature and meets regulatory safety standards when used as directed.

We recommend taking 1 capsule per day.

To boost the longevity effects of NR and improve activation of the key anti-ageing pathways see our blogs on NMN and on Longevity.

We think the best Longevity supplements are as below. To make life easy we have put together in our Longevity pack.

1. Nicotinamide Riboside (NR) Our high-purity NR supplement (99.5%) is rapidly absorbed and efficiently converted into NAD+, powering energy production, supporting mitochondrial function, and activating longevity genes such as sirtuins
2. Quercetin This flavonoid helps preserve NAD+ levels by inhibiting CD38, an enzyme that breaks NAD+ down in the body. By reducing NAD+ depletion, Quercetin amplifies the benefits of NR and supports immune resilience and cellular repair.
3. Resveratrol A powerful polyphenol that works synergistically with NR by activating the sirtuin pathway, which plays a central role in DNA repair, inflammation control, and healthy ageing. We use trans-resveratrol, the most bioactive form.
4. Coenzyme Q10 Essential for mitochondrial energy production and acting as a potent antioxidant, CoQ10 helps reduce oxidative stress and supports heart and brain health. It has been shown to improve exercise performance and delay fatigue. Its synthesis in the body also relies on key nutrients including vitamins B2, B3, B5, B6, B9 and C.
5. D3 and K2 These vitamins work together to support bone health, cardiovascular function, and immune defence — all of which are essential for healthy ageing.
6. B complex methylated active form A complete B-vitamin complex in active, bioavailable forms, supporting methylation, energy metabolism, brain function, and the biosynthesis of key cellular cofactors.

While both NR (nicotinamide riboside) and niacin (vitamin B3) are precursors to NAD+, NR is a more efficient and better-tolerated option for boosting NAD+ levels and activating key longevity pathways, including sirtuins.

Traditional forms of vitamin B3, such as niacin and nicotinamide (NAM), need to be converted by the body through several steps before they become NAD+. NAM in particular must first be converted into NMN, and then into NAD+, which is a slower and less direct process compared to NR.

There’s also a critical difference when it comes to sirtuin activation. Sirtuins are enzymes that rely on NAD+ to function and play a major role in DNA repair, cellular metabolism, and healthy ageing. When NAD+ is used by sirtuins, it is broken down into NAM. If too much NAM builds up, it can actually inhibit sirtuin activity cancelling out many of the benefits of NAD+ supplementation.

Additionally, high doses of niacin or nicotinamide often cause uncomfortable side effects such as skin flushing, which many users find unpleasant. In contrast, NR is better tolerated, causes no flushing, and has been shown in studies to reliably increase NAD+ levels in humans.

For those looking to support healthy ageing, energy production, and cognitive function, NR is the superior and scientifically preferred form of vitamin B3 for increasing NAD+ naturally and safely.

There is growing scientific interest in the role of NR (Nicotinamide Riboside) in metabolism and weight management. Animal studies have shown that boosting NAD+ through NR can improve mitochondrial function, increase energy expenditure, and enhance the breakdown of fat all of which are important processes in managing body weight.

In human trials, results have been more mixed. For example, a study involving menopausal women taking 250mg of NAD+ precursors daily did not show significant weight loss, though the dosage used was relatively low. At higher doses, such as 500mg or more per day, the potential metabolic benefits may be more pronounced particularly when combined with a healthy diet and regular exercise.

There is also interest in NR’s role in activating sirtuins a group of proteins that regulate metabolism, inflammation, and fat storage. Diets like the SIRT diet, which combines sirtuin-activating foods with targeted supplements, have been linked to weight loss outcomes. While we’re not promoting NR as a weight loss supplement, it can support metabolic health and energy regulation when used as part of a broader lifestyle programme.

To get the best results, NR should be taken consistently alongside a balanced diet, regular physical activity, and healthy sleep habits.

NAD+ and NR are not the same thing and one isn’t necessarily “better,” but rather plays a different role in the body. NAD+ (nicotinamide adenine dinucleotide) is a vital molecule required for energy production, DNA repair, and healthy ageing. However, taking NAD+ directly as a supplement is not an effective way to raise cellular NAD+ levels.

This is because NAD+ cannot easily cross cell membranes. No dedicated transporter has been conclusively identified to deliver NAD+ directly into cells. Instead, NAD+ must first be broken down into precursors such as NR or NMN, which can then be absorbed and converted back into NAD+ inside the cell.

NR (Nicotinamide Riboside) is one of the most efficient and bioavailable ways to increase NAD+ in the body. It is rapidly absorbed and has been shown in multiple human studies to significantly raise NAD+ levels. Once inside the cell, NR is converted into NMN and then into NAD+, fuelling mitochondrial energy production and activating longevity pathways like sirtuins.

In 2018, researchers (Grozio et al.) identified a transporter, Slc12a8, that may help move NMN into cells but this mechanism appears to be tissue-specific and is still being studied. For now, the consensus remains that supplementing with NR is one of the most reliable and science-backed ways to increase NAD+ levels safely and effectively.

Each capsule contains 500mg of >99% pure Nicotinamide Riboside Chloride (NR), a highly bioavailable and research-backed precursor to NAD+. There are no fillers, additives, or bulking agents, just clean, high-purity NR to support energy, cellular health, and longevity.

The capsule is made from plant-based HPMC (Hydroxypropyl Methylcellulose), making it fully suitable for vegans and vegetarians.

1. Lapatto HAK etal Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study. Sci Adv. 2023 Jan 13;9(2):eadd5163. doi: 10.1126/sciadv.add5163. Epub 2023 Jan 13. PMID: 36638183; PMCID: PMC9839336.
2. Berven H, Kverneng S, Sheard E, Søgnen M, Af Geijerstam SA, Haugarvoll K, Skeie GO, Dölle C, Tzoulis C. NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson's disease. Nat Commun. 2023 Nov 28;14(1):7793. doi: 10.1038/s41467-023-43514-6. PMID: 38016950; PMCID: PMC10684646.
3. Martens CR, Denman BA, Mazzo MR, Armstrong ML, Reisdorph N, McQueen MB, Chonchol M, Seals DR. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+in healthy middle-aged and older adults. Nat Commun. 2018 Mar 29;9(1):1286. doi: 10.1038/s41467-018-03421-7. PMID: 29599478; PMCID: PMC5876407.
4. NAD + Intermediates: The Biology and Therapeutic Potential of NMN and NR Cell Metab 2018
5. NAD+ metabolism and its roles in cellular processes during ageing Nature 2020
6. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds Nature 2016
7. Supplementation with NAD+ and Its Precursors to Prevent Cognitive Decline across Disease Contexts Nutrients August 2022
8. Mitochondrial Sirtuins in Skin and Skin Cancers Photochem Photobiol 2020
9. NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential nature 2020
10. Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and womam Nature Aug 2022
11. Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility Endo 2021
12. Resveratrol Increases Intracellular NAD+ Levels Through Up regulation of The NAD+ Synthetic Enzyme Nicotinamide Mononucleotide Adenylyltransferase Nature Precedings 2010
13. Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38 Diabetes 2013
14. Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study Nutrients 2022