Phosphatidylcholine is a phospholipid integral to cell membranes and plays a significant role in cognitive health and liver function. It is found in various food sources, including eggs, soybeans, sunflower seeds, and mustard.
The need to know
What are the benefits?
Memory and Brain Gain
Increases energy production in the brain
Phosphatidylcholine's involvement in cell membrane composition and maintenance is critical to its role in health. The phospholipid bilayer, where phosphatidylcholine is a significant component, ensures the integrity and function of cells, enabling the transport of molecules in and out of cells and facilitating cell-to-cell communication.
In the context of cognitive health, phosphatidylcholine is metabolised to produce choline, which is then used to produce acetylcholine. Acetylcholine is a neurotransmitter essential for memory formation, learning, and other cognitive functions. Thus, phosphatidylcholine supplementation can support cognitive health by increasing the availability of choline for acetylcholine synthesis.
Regarding liver health, phosphatidylcholine is instrumental in the process of very low-density lipoprotein (VLDL) production, which is necessary for the transport and metabolism of fats. A lack of phosphatidylcholine can decrease VLDL production, leading to an accumulation of fats in the liver, thereby contributing to fatty liver disease. Therefore, phosphatidylcholine supplementation may aid in maintaining liver health by promoting proper fat transport and metabolism.
How will I know its working?
Positive effects of phosphatidylcholine supplementation can manifest as improved memory and cognitive function, better liver health, and potential improvements in mood and anxiety levels.
When to take it?
Take 1 capsule daily with food and water, unless specified otherwise on the sachet.
Serving Size 1 Vegetarian Capsule
Per Serving% Daily
Phosphatidylcholine (from soy lecithin)
* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value not established.
Soy Lecithin And Capsule Shell (Gelatine, Glycerine And Water). Other Phospholipids: Phophatidylserine, Phosphatidylethanolamine And Phosphatidylinositol
Did you know?
Aside from its occurrence in various foods, Phosphatidylcholine is also produced in the human body, primarily via the CDP-choline pathway.
In addition to its role in cognitive and liver health, phosphatidylcholine is also involved in other biological functions, including lipid metabolism and cellular communication.
Phosphatidylcholine is the second-most abundant phospholipid in the human body, and it makes up about 50% of the total phospholipids in bile.
Publications you might find interesting
Want to go a bit deeper?
The latest research
1. Zeisel, S. H., & da Costa, K. A. (2009). Choline: an essential nutrient for public health. Nutrition reviews, 67(11), 615-623.
2. Michel, V., & Bakovic, M. (2007). Lipid rafts in health and disease. Biology of the Cell, 99(3), 129-140.
3. Li, Z., Agellon, L. B., Allen, T. M., Umeda, M., Jewell, L., Mason, A., & Vance, D. E. (2006). The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. Cell Metabolism, 3(5), 321-331.
4. Ferreira, I. D., do Rosário, V. E., & Cravo, P. V. L. (2006). Real-time quantitative PCR with SYBR Green I detection for estimating copy numbers of nine drug resistance candidate genes in Plasmodium falciparum. Malaria journal, 5(1), 1-7.
5. Kusumoto, Y., Irie, M., Iwabuchi, Y., & Kitasato, H. (2016). Phosphatidylcholine and Alzheimer’s Disease. The Open Medicinal Chemistry Journal, 10, 8-21.
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