Vitamin D3 (cholecalciferol) and Vitamin K2 (menaquinone) are both fat-soluble vitamins, each serving essential roles in the body.
However, factors like limited sunlight exposure, skin type, age, and geographical location can limit this process, making dietary intake or supplementation necessary. Vitamin D3 supports several bodily processes, including calcium absorption for bone growth and maintenance, normal immune function, brain health, mood regulation, and energy levels. Optimal levels of Vitamin D3 are above 100 nmol/L.
On the other hand, Vitamin K2 is less well-known but equally crucial for health. It mainly exists in two forms, MK-4 and MK-7, with MK-7 having a longer half-life and thus more bioavailable. This vitamin plays a key role in activating proteins responsible for incorporating calcium into the bones (osteocalcin) and inhibiting calcium deposition in artery walls (Matrix Gla Protein), supporting bone and cardiovascular health.
The need to know
What are the benefits?
Boosted Vitamin 4000 IU D3 + K2
Supports bone health
Boosts energy levels
Vitamin D3, known as the "sunshine vitamin, " is essential in many physiological functions, such as calcium absorption in the gut, bone growth and maintenance, immune regulation, and mood enhancement. It's critical to ensure calcium and phosphate adequate serum concentrations for normal bone mineralisation.
Vitamin K2 (as menaquinone-7 or MK-7) activates proteins involved in calcium metabolism, such as osteocalcin, which incorporates calcium into bones, and Matrix Gla Protein (MGP), which inhibits arterial calcification. Thus, it not only assists Vitamin D3 in promoting bone health but also ensures that the absorbed calcium is effectively used in the body and does not contribute to arterial calcification.
Optimal magnesium and B12 levels are necessary to maximise the benefits of Vitamin D, while Vitamin K2's co-administration is crucial to prevent potential side effects related to unregulated calcium metabolism.
How will I know its working?
You may experience stronger bones, improved mood and energy levels, and enhanced immune function.
Since effects can be subtle and long-term, regular lab tests can verify improved blood vitamin D and calcium levels.
When to take it?
Take 1 tablet daily with food and water, unless specified otherwise on the sachet.
Serving Size 1 Vegetarian Capsule
Per Serving% Daily
Vitamin D (4,000 IU)
Vitamin K2 (MK-7)
* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value not established.
Vitamin D3 is synthesised in the skin in response to sunlight, but factors like geographic location, time of year, and sunscreen use can affect production.
Vitamin K2 is naturally found in high quantities in fermented foods, like natto, a traditional Japanese dish made from fermented soybeans.
The testosterone-producing Leydig cells in men have vitamin D receptors and reduced production when vitamin D levels are low.
Publications you might find interesting
Want to go a bit deeper?
The latest research
1. Institute of Medicine, Food and Nutrition Board. (2010). Dietary Reference Intakes for Calcium and Vitamin D. National Academy Press.
2. Pludowski P, et al. (2013). Vitamin D supplementation guidelines. J Steroid Biochem Mol Biol, 175:125-135.
3. Schwalfenberg GK. (2017). Vitamins K1 and K2: The Emerging Group of Vitamins Required for Human Health. Journal of Nutrition and Metabolism.
4. Maresz K. (2015). Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health. Integr Med (Encinitas).
5. Geleijnse JM, et al. (2004). Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr.
6. Chang SW, Lee HC. Vitamin D and health - The missing vitamin in humans. Pediatr Neonatol. 2019;60(3):237-244. doi:10.1016/j.pedneo.2019.04.007
7. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008;87(4):1080S-6S. doi:10.1093/ajcn/87.4.1080S
8. Bergqvist C, Ezzedine K. Vitamin D and the skin: what should a dermatologist know?. G Ital Dermatol Venereol. 2019;154(6):669-680. doi:10.23736/S0392-0488.19.06433-2
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