Urolithin A is a unique molecule that renews our cellular mitochondria the powerhouses of our cells.
Not only does this lead to improved energy production and help athletes to recover, but it also makes Urolithin A a potent longevity molecule.
Urolithin A promotes a process called mitophagy, which cleans up defective mitochondria and promotes the recycling and cleansing of the energy processes in the body.
This leads to better energy production at a cellular level, both physical and mental. Improved muscle strength and improved skin health.
The need to know
What are the benefits?
Helps maintain function
May help extend lifespan, and reduce age-related inflammation
One of the most significant aspects of Urolithin A is its ability to improve mitochondrial function. Mitochondria are the "powerhouses" of the cell, responsible for generating energy. As we age, mitochondrial function tends to decline, leading to reduced cellular energy, increased oxidative stress, and, ultimately, cellular senescence or death.
Urolithin A has been shown to enhance mitophagy, the process by which damaged mitochondria are removed and recycled. This is crucial because the accumulation of dysfunctional mitochondria can lead to cellular damage and contribute to ageing. By promoting mitophagy, Urolithin A helps to maintain a healthy pool of functional mitochondria, thereby potentially extending cellular lifespan.
Chronic, low-grade inflammation is another hallmark of ageing, often called "inflammageing." This type of inflammation is implicated in a variety of age-related diseases, including cardiovascular disease, diabetes, and neurodegenerative disorders. Urolithin A has demonstrated anti-inflammatory properties, reducing markers of inflammation such as C-reactive protein (CRP). By mitigating chronic inflammation, Urolithin A may help slow the ageing process and extend lifespan.
The effects of Urolithin A are not limited to a single tissue or organ system. It has shown benefits in multiple tissues affected by ageing, including physical energy and joint cartilage. This multi-tissue effect suggests that Urolithin A could have a more systemic impact on ageing, potentially offering a more holistic approach to longevity.
Several clinical trials have demonstrated the safety and efficacy of Urolithin A in improving overall health and mitochondrial health in middle-aged and elderly individuals. These trials provide strong evidence for its potential role in promoting healthy ageing.
Furthermore, this compound has been shown to cross the blood-brain barrier, suggesting that it could have neuroprotective effects, although more research is needed in this area.
How will I know its working?
Users might notice improved endurance, vitality, and possibly even cognitive clarity. Over the long term, there may be slowed age-related decline and overall vitality.
When to take it?
Take 1 capsule daily with food and water, unless specified otherwise on the sachet.
Per Serving% Daily
99% Urolithin A
* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value not established.
Brown Rice Flour (GF), HPMC casule
Did you know?
Natural Origins: Urolithin A isn't directly found in foods. Instead, we get it from the gut microbiome breaking down ellagitannins from foods like pomegranates and berries.
Blood-Brain Barrier: One of the few compounds that can cross the blood-brain barrier, suggesting potential for brain health.
Clinical Trials: Preliminary human trials have shown that Urolithin A can improve mitochondrial and cellular health, positioning it as a promising agent for longevity.
Publications you might find interesting
Want to go a bit deeper?
The latest research
1. Singh, R., Chandrashekharappa, S., Bodduluri, S. R., Baby, B. V., Hegde, B., Kotla, N. G., ... & Langille, M. G. I. (2019). ""Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway."" Nature Communications, 10(1), 1-18.
2. Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Wang, X. (2016). ""Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents."" Nature Medicine, 22(8), 879-888.
3. Andreux, P. A., Blanco-Bose, W., Ryu, D., Burdet, F., Ibberson, M., Aebischer, P., ... & Auwerx, J. (2019). ""The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans."" Nature Metabolism, 1(6), 595-603.
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