GLP-1 Metabolic Balance (PCOS & androgenic insulin support)

This stack is designed for women with androgen-dominant PCOS or insulin resistance. It targets the root hormonal drivers insulin and androgens using a synergistic blend of nutrients that support glucose metabolism, hormone regulation, and ovarian health.

PCOS often begins with insulin resistance, which raises insulin levels and drives ovarian androgen production. Inositol improves insulin receptor sensitivity, while Berberine enhances glucose uptake through AMPK activation.

Chromium supports insulin signalling, and Magnesium acts as a cofactor for over 300 enzymes involved in glucose metabolism.
NAC improves glutathione status and reduces oxidative stress, which in turn lowers testosterone and inflammation.

Vitamin D3 and K2 modulate sex hormone-binding globulin whilst inhibiting myostatin and muscle and ovarian signalling, and Saw Palmetto inhibits 5-alpha reductase to reduce DHT formation. Together, these ingredients help reset metabolic and hormonal balance.

PCOS with androgen dominance is fundamentally a metabolic-hormonal disorder driven by insulin resistance.
When cells become less responsive to insulin, the pancreas compensates by producing more. These elevated insulin levels overstimulate ovarian theca cells, triggering excess androgen production (testosterone and DHT). This hormonal imbalance disrupts ovulation, promotes acne and hair growth, and increases visceral fat storage, creating a self-reinforcing loop.

This stack targets the root cause of that loop at multiple points:

Inositol (myo- and D-chiro forms) acts as an intracellular insulin messenger, improving insulin receptor sensitivity and glucose uptake in both muscle and ovarian tissue. It helps to normalise insulin signalling, reduce circulating insulin, and restore ovulation in many women with PCOS.

Berberine activates AMP-activated protein kinase (AMPK), the same metabolic switch turned on by exercise and fasting, improving glucose disposal and lowering insulin levels. It also beneficially alters the gut microbiome, enhancing GLP-1 secretion and reducing systemic inflammation.

Chromium picolinate further enhances insulin receptor efficiency by promoting the binding of insulin to its receptor, stabilising blood glucose, and reducing post-meal glucose spikes.

Magnesium glycinate supports over 300 enzymatic reactions in carbohydrate metabolism and stabilises ATP-dependent insulin transport. Low magnesium levels are common in insulin-resistant states and worsen metabolic dysfunction.

N-Acetyl Cysteine (NAC) replenishes glutathione, the body’s master antioxidant, protecting ovarian tissue from oxidative stress while improving insulin sensitivity and reducing testosterone production.

Vitamin D3 and K2 together enhance insulin receptor expression and modulate sex hormone–binding globulin (SHBG), helping to reduce free androgen levels and support ovarian signalling and calcium balance.

Saw Palmetto inhibits 5-alpha-reductase, the enzyme that converts testosterone into DHT, helping to reduce acne, scalp hair loss, and other androgen-related symptoms.

Together, these ingredients improve the way your body responds to insulin, reduce androgen excess, and restore a healthy communication loop between the brain, ovaries, and metabolism the foundation for hormonal and metabolic reset.

Take one sachet daily with food (or as directed by your practitioner). For best results, follow consistently for 12 weeks while maintaining balanced nutrition and physical activity.

You may notice more stable energy levels, improved skin clarity, fewer sugar cravings, and more regular menstrual cycles within 6–12 weeks. Blood tests may show improved fasting insulin and lower testosterone.