GLP-1 Hormone Balance (Menopause & Metabolic Support)

As oestrogen levels decline during perimenopause and menopause, metabolism slows, fat distribution shifts to the abdomen, and insulin sensitivity falls. Many women also use GLP-1 receptor agonists to manage weight which can further alter nutrient absorption, muscle tone, and energy levels. This stack is designed to support the body’s adaptive mechanisms, helping maintain hormonal balance, mitochondrial activity, and nutrient utilisation during this transition.

The menopausal transition and GLP-1 use both influence how the body regulates energy, glucose, and hormones. Oestrogen decline reduces insulin sensitivity and mitochondrial activity, while GLP-1 therapy can slow gastric emptying and reduce calorie intake sometimes lowering micronutrient availability and metabolic rate.

• Berberine activates AMPK, the body’s key metabolic switch, promoting efficient glucose use and supporting mitochondrial energy production. It complements GLP-1 therapy by helping maintain metabolic flexibility and insulin balance.
• DIM (Diindolylmethane) supports healthy oestrogen metabolism through liver detoxification pathways, helping balance symptoms linked to oestrogen dominance.
• Magnesium glycinate supports more than 300 enzyme systems, aiding glucose control, energy release, and muscle relaxation valuable where GLP-1 therapy may reduce dietary magnesium intake.
• Alpha-lipoic acid (ALA) enhances mitochondrial function and helps recycle antioxidants, supporting metabolic health and skin vitality.
• Omega-3 fatty acids contribute to normal heart and brain function and help reduce inflammation that can increase with declining hormones.
• Vitamin D3 and K2 work together to maintain bone and immune health, as well as normal calcium utilisation.
• Rhodiola and Ashwagandha are adaptogens that help balance cortisol and reduce fatigue, promoting resilience during both hormonal and metabolic transitions.

Collectively, these nutrients and botanicals support the body’s capacity to adapt helping maintain energy, mood, and metabolic health throughout menopause and during GLP-1 therapy.

Take two sachets daily with meals or as directed by your practitioner. For best results, maintain consistent use for 12 weeks alongside balanced nutrition, strength training, and adequate protein, particularly if using GLP-1 medication.

You may notice steadier energy, improved mood and sleep, fewer hot flushes, and reduced abdominal fat within 4-8 weeks. Continued use may support sustained weight stability and metabolic health during GLP-1 therapy and menopause.