GLP-1 Core Balance: Metabolic Tone (women)

Many women with a normal BMI still accumulate visceral fat stored around the organs, which increases inflammation, driving autoimmune disease and insulin resistance. This stack targets metabolic flexibility: the ability to switch between fat and glucose for fuel. It’s especially beneficial for women transitioning off GLP-1 therapy, where appetite suppression may have reduced muscle tone and nutrient intake.

• Inositol Myo-inositol is involved in insulin receptor signalling and ovarian hormone balance. It supports normal glucose metabolism and is widely used in women with insulin-related cycle and weight issues, making it ideal for “skinny-fat” phenotypes where standard markers can look deceptively normal.

• Chromium contributes to the maintenance of normal blood glucose levels. It supports insulin action at the receptor level, helping the body handle carbohydrates more efficiently during GLP-1 therapy or a calorie deficit.

• Glycine is A simple amino acid that supports phase II liver detoxification, glutathione production and healthy sleep architecture. In the GLP-1 context, it helps with evening relaxation, muscle recovery and maintaining antioxidant defences during lower calorie intake.

• Magnesium glycinate supports more than 300 enzyme systems, aiding glucose control, energy release, and muscle relaxation valuable where GLP-1 therapy may reduce dietary magnesium intake.

• Vitamin D3 + K2 Vitamin D contributes to normal immune function, muscle function and the maintenance of normal bones; vitamin K contributes to normal blood clotting and bone maintenance. Adequate vitamin D status is also closely linked to metabolic and mood health, which is particularly relevant for women on GLP-1s with low dietary intake.

• NR – nicotinamide riboside) A precursor to NAD⁺, a central cofactor in mitochondrial energy production and cellular repair. Supporting NAD⁺ helps maintain energy, mitochondrial function and metabolic flexibility during weight-loss phases, when low energy intake can otherwise push the system towards fatigue rather than regeneration.

• Curcumin, the active compound in turmeric, is used to support a healthy inflammatory response. Visceral fat is metabolically active and drives low-grade inflammation; curcumin helps modulate key pathways associated with this process, supporting joint comfort and overall metabolic health.

• Ashwagandha is an adaptogenic herb traditionally used to support the stress response, improve sleep quality, and enhance resilience. It helps balance the HPA axis and may support standard cortisol patterns, which are often disturbed in women with central fat gain despite a normal BMI.

• B-complex B vitamins contribute to normal energy-yielding metabolism, reduction of tiredness and fatigue, and normal psychological function. They support methylation, neurotransmitter production, and mitochondrial function – all of which are crucial during caloric restriction and body composition changes.

• Liposomal resveratrol (×1) A polyphenol associated with healthy ageing pathways and vascular function. In liposomal form, it has improved bioavailability. Combined with NR, it complements NAD⁺ support and may help maintain endothelial health and metabolic signalling during GLP-1-assisted weight loss.

Take two sachets daily, preferably with meals. For ongoing metabolic support, use consistently particularly after completing GLP-1 therapy or a calorie-restricted plan.

You may notice improved energy, better body composition (flatter abdomen, improved tone), and a more stable appetite. Blood markers such as fasting insulin or triglycerides may improve over time.